CTLA-4 inhibitor

Research use only, not for human use.

CTLA-4 inhibitor is a potent CTLA-4 inhibitor.

MDK24720 is a CTLA-4 inhibitor. MDK24720 has CAS#635324-72-0, in which the last 5 digital was used in the code name. CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In Systemic Lupus Erythematosus (SLE), the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active SLE.

MDK24720;MDK-24720; CTLA-4 inhibitor

Angiogenesis

IGF-1R

CTLA-4

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635324-72-0

427.11

C21H13F4N5O

98%

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c12c(nc3c(c1[nH]n(c2=O)c1ccc(cc1)F)cnn3C)c1cc(ccc1)C(F)(F)F

2-(4-Fluoro-phenyl)-6-methyl-4-(3-trifluoromethyl-phenyl)-1,6-dihydro-2H-1,2,5,6,7-pentaaza-as-indacen-3-one

(-20℃)

With Ice Pack

≥ 2 years